Drastically cutting calories lowers some risk factors for age-related diseases​​

The largest study to date of sustained calorie reduction in adults shows that it does not produce all of the metabolic effects associated with longevity that have been found in animal studies. Severely cutting calorie intake, however, did appear to lower the risk of cardiovascular disease and make people more sensitive to insulin, according to John O. Holloszy, MD, principal investigator at the study’s Washington University clinical site.

Gastric bypass surgery lowers women’s alcohol tolerance​

Women who have gastric bypass surgery to lose weight should keep a close eye on their alcohol consumption, according to a study at Washington University School of Medicine in St. Louis. The researchers found that changes in how alcohol is metabolized after surgery can speed its delivery into the bloodstream, resulting in earlier and higher peaks in blood-alcohol levels.

Not all obese people develop metabolic problems linked to excess weight​​​​

New research demonstrates that obesity does not always go hand in hand with metabolic changes in the body that can lead to diabetes, heart disease and stroke. Washington University School of Medicine researchers found that a subset of obese people do not have common metabolic abnormalities associated with obesity, and they don’t develop them when they gain more weight.​

Strategy proposed for preventing diseases of aging

More efforts should be directed at promoting interventions that have the potential to prevent multiple chronic diseases and extend healthy lifespans. School of Medicine and other researchers write in Nature that economic incentives in biomedical research and health care reward treating disease more than promoting good health.

Smoking may dull obese women’s ability to taste fat and sugar

People who smoke also tend to eat more high-fat foods. So do obese people. Now, a team of researchers, including M. Yanina Pepino, PhD, at the School of Medicine, has found that obese women who also smoke have a difficult time perceiving fat and sweetness in their food. And that could lead them to eat even more fatty foods.
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