oncology

Arnold Bullock, MD, is highly regarded for his expertise in urology and his community outreach efforts, which are helping to reduce cancer disparities. He has been named the inaugural Alan A. and Edith L. Wolff Distinguished Professor of Urology at the School of Medicine.

The Molecular Imaging Center at Washington University School of Medicine in St. Louis has received a five-year, $7.1 million grant to develop innovative ways to study cancer and other disorders by monitoring the activity of cells and proteins inside the body.

Teresa J. Vietti, M.D., a pediatric oncologist who earned the nickname, “the mother of pediatric cancer therapy,” died Jan. 25, 2010. She was 82.

When estrogen-lowering drugs no longer control metastatic breast cancer, the opposite strategy might work. Raising estrogen levels benefited 30 percent of women whose metastatic breast cancer no longer responded to standard anti-estrogen treatment, according to research conducted at the School of Medicine and collaborating institutions.

Genes respond to chemo drugOncologists aren’t sure exactly why patients with the same cancer often respond very differently to the same treatment, but a growing body of evidence suggests the answer lies somewhere in the genes. Now researchers at the School of Medicine have become the first to profile the activity of whole sets of genes involved in processing chemotherapeutic drugs.

A look at the activity of 24 genes in 52 patients as those genes respond to the chemotherapy drug 5-fluorourancilOncologists aren’t sure exactly why patients with the same cancer often respond very differently to the same treatment, but a growing body of evidence suggests the answer lies somewhere in the genes. Now researchers at Washington University School of Medicine in St. Louis have become the first to profile the activity of whole sets of genes involved in processing chemotherapeutic drugs.

Keith Brandt performs a breast reconstruction using the TRAM flap procedure.When a breast cancer patient requires a mastectomy, cancer surgeons and reconstructive plastic surgeons at the Siteman Cancer Center at Barnes-Jewish Hospital and WUSM now perform a technique called the TRAM (traverse rectus abdominus myocutaneous) flap procedure, which allows surgeons to use the patient’s own tissues to recreate a natural breast.

GrigsbyDoctors regularly use positron emission tomography (PET) scans to diagnose cervical cancer, taking advantage of the technique’s ability to highlight metabolic differences in cancerous tissues. But PET is rarely used for follow-up assessment of cervical cancer patients after treatment. A study in the June 1 issue of Journal of Clinical Oncology shows that post-treatment PET scans could help physicians better predict which patients are largely cancer-free as a result of their treatment and which patients may soon be likely to need additional treatment.

A new technique in development may produce quick and efficient radiation dosing.Researchers at Washington University in St. Louis have developed a technique that drastically decreases the time a radiation oncologist spends calculating radiation dosages and also provides a more carefully controlled dosage with less damage to nearby healthy tissues. They have applied a mathematical tool called wavelet analysis to radiation dose distributions simulations and have sped up the dose calculations by a factor of two or more over the standby dose calculation.