stroke

Red areas of the circled leg in the right image show increased blood flow due to angiogenic cells.To speed healing at sites of injury – such as heart muscle after a heart attack or brain tissue after a stroke – doctors would like to be able to hasten the formation of new blood vessels. One promising approach is to “mobilize” patients’ blood vessel-forming cells, called angiogenic cells, so these cells can reach the injured area. Recently, researchers at Washington University School of Medicine in St. Louis demonstrated that a drug called AMD3100 can mobilize angiogenic cells from bone marrow of human patients in a matter of hours.

Areas activated by tasks designed to stimulate voluntary attentionThe first direct analysis of the interactions between two brain networks that govern visual attention may help researchers at the School of Medicine develop treatments for stroke patients with a condition known as spatial neglect. These patients have difficulty focusing on or paying attention to stimuli in the left half of their visual field.

Among the areas activated by tasks designed to stimulate voluntary attention were the intraparietal sulcus and frontal eye fields, both believed to be part of a network of neurons called the dorsal attention system.The first direct analysis of the interactions between two brain networks that govern visual attention may help researchers at Washington University School of Medicine in St. Louis develop treatments for stroke patients with a condition known as spatial neglect. These patients have difficulty focusing on or paying attention to stimuli in the left half of their visual field. They may forget to shave the left side of their face, fail to eat food on the left side of a plate or seem to be unaware that their left arm belongs to them. However, researchers have found that if they explicitly tell these people to pay attention to their left side, for a brief time they can do so.

Sen. Jim Talent, Michael DeBaun and Isaac Singleton Jr. help raise awareness about sickle cell disease at a recent stamp dedication ceremony.In sickle cell disease, red blood cells change from their normal round shape to a curved, or sickle-shape. Sickle-shaped cells become stuck in blood vessels, causing damage to tissues and organs. WUSM pediatric hematologist Michael DeBaun says that ongoing blood transfusion therapy is vitally important for children with sickle cell disease, and treatment requires a sufficient supply of blood from African-American donors. “Black History Month is an ideal time to encourage African-Americans to come out and donate blood,” he says.

Sen. Jim Talent, Michael DeBaun and Isaac Singleton Jr. help raise awareness about sickle cell disease at a recent stamp dedication ceremony.In sickle cell disease, red blood cells change from their normal round shape to a curved, or sickle-shape. Sickle-shaped cells become stuck in blood vessels, causing damage to tissues and organs. WUSM pediatric hematologist Michael DeBaun says that ongoing blood transfusion therapy is vitally important for children with sickle cell disease, and treatment requires a sufficient supply of blood from African-American donors. “Black History Month is an ideal time to encourage African-Americans to come out and donate blood,” he says.

Approximately 1 million stroke victims suffer from a condition called aphasia, which can affect reading, writing, speaking or understanding speech. Generally, speech therapists rely on their own experience and intuition to determine treatment for these patients, but a multidisciplinary research team from the School of Medicine has developed a speech rehabilitation program using the same evidence-based approach used by physicians and surgeons.

Researchers discovered activity in a part of the brain called the extrastriate body both when subjects viewed body parts and when they pointed to an object.Although we don’t often think about it, the brain is a very complicated place. Even the simple act of pointing at an object requires an intricate network of brain activity. Scientists traditionally thought this network included a one-way “information highway” between the brain’s visual system and its motor and sensory systems, but research at Washington University School of Medicine in St. Louis now challenges that long-held theory. The study demonstrates that the brain’s visual system is responsible not only for seeing and perceiving objects outside the body, but also is involved when individuals sense and manipulate their own bodies.

In this micrograph of a neuron, green dye highlights proteins linked to nerve cell damage and death during stroke.Brain cells in danger of exciting other nearby brain cells to death may be able to close temporarily, according to new research from Washington University School of Medicine in St. Louis. Scientists simulated stroke-like conditions in cultured rat brain cells that use glutamate, an excitatory chemical messenger linked to nerve damage and death during strokes. But when they created those conditions, the researchers found that glutamate transmission was suppressed in what may be an attempt by neurons to limit the damage caused by catastrophic events such as strokes.

A major factor contributing to Americans’ increasing body sizes appears to be increasing portion sizes.Obesity puts people at risk for heart disease, diabetes, stroke, high blood pressure and cancer. It also decreases quality of life. But that’s not stopping Americans from eating and drinking more than ever before. Almost two-thirds of Americans are either overweight or obese, and a major factor contributing to increasing body sizes appears to be increasing portion sizes. Obesity researcher Samuel Klein, M.D., the Danforth Professor of Medicine and Nutritional Science at Washington University School of Medicine in St. Louis, says the obesity epidemic continues to get worse in spite of a great deal of research about the dangers of being overweight and increasing numbers of people who are trying to lose weight. Part of the problem is that many people tend to eat what is put in front of them, and serving sizes are larger than ever before.