Setton’s research focuses on the role of mechanical factors in the degeneration and repair of soft tissues of the musculoskeletal system, including the intervertebral disc, articular cartilage and meniscus. In the lab, her work focuses on engineering and evaluating novel materials for tissue regeneration and drug delivery to treat musculoskeletal disease.
The Setton lab leads an interdisciplinary team researching potential treatments for intervertebral disc disease.
As scientists try to find therapy options to fight back and neck pain, considerable interest exists in harnessing stem cells to restore nucleus pulposus, the chief material in discs. Previous research shows human induced pluripotent stem cells (hiPSCs) can express markers for a wide variety of cells, including those that secrete NP. A collaborative team of scientists at Washington University has developed a new process to generate NP-like cells from hiPSCs.
With a new $1.7 million award from the National Institutes of Health, a team from Washington University in St. Louis plans to develop a silk-based system to better alleviate the pain and discomfort of osteoarthritis.
Lori Setton, a renowned researcher into the role of the degeneration and repair of the body’s soft tissues, has been named the Lucy and Stanley Lopata Distinguished Professor of Biomedical Engineering at Washington University in St. Louis.