Pappu’s research interests are focused on intrinsically disordered proteins (IDPs), specifically their roles in transcriptional regulation, receptor mediated cell signaling, and cellular stress response. The Pappu lab has pioneered the combined use of polymer physics theories, novel homegrown computational methods, and experiments to probe the functional and phenotypic impacts of IDPs. Professor Pappu’s lab also has a significant effort that is focused on neurodegeneration in Huntington’s and Alzheimer’s diseases. The central goal is to understand how protein aggregation and protein homeostasis pathways collude to give rise to neuronal death as a function of aging.
Membraneless organelles are tiny droplets inside a single cell, thought to regulate everything from division, to movement, to its very destruction. New research from engineers at Washington University in St. Louis uncovers the principles underlying the formation and organization of membraneless organelles.
Engineers at Washington University in St. Louis and Princeton University developed a new way to dive into the cell’s tiniest and most important components. What they found inside membraneless organelles surprised them, and could lead to better understanding of fatal diseases such as cancer, Huntington’s and ALS.
Researchers from Washington University in St. Louis and St. Jude Children’s Research Hospital in Memphis made a discovery that uncovers the molecular logic of how dividing cells are stopped in their tracks. The team zeroed in on a specific protein, whose job is to stop a cell from dividing or to slow the division.
Rohit V. Pappu, the Edwin H. Murty Professor of Engineering in the School of Engineering & Applied Science at Washington University in St. Louis, has received two grants from the National Institutes of Health totaling more than $4.5 million to study the causes behind Huntington’s disease that may ultimately provide clues for a treatment or cure.