How to stop dividing cancer cells in their tracks

Researchers from Washington University in St. Louis and St. Jude Children’s Research Hospital in Memphis made a discovery that uncovers the molecular logic of how dividing cells are stopped in their tracks. The team zeroed in on a specific protein, whose job is to stop a cell from dividing or to slow the division.

Dudukovic receives Neal Amundson Award

Milorad (Mike) Dudukovic, of the School of Engineering & Applied Science at Washington University in St. Louis, has received the prestigious Neal R. Amundson Award for Excellence in Chemical Reaction Engineering from the International Symposia on Chemical Reaction Engineering.
New research from engineers at Washington University in St. Louis suggests elastic bands in the coronary arteries might be a contributing factor to plaque buildup.

Research suggests new contributor to heart disease

Medical professionals have long known that the buildup of plaque in arteries can cause them to narrow and harden, potentially leading to a whole host of health problems — including heart attack, heart disease and stroke. While high blood pressure and artery stiffness are often associated with plaque buildup, new research from engineers at Washington University in St. Louis shows they are not the direct causes. Their findings suggest a new culprit: elastic fibers in the arterial wall.
St. Louis summers can be hot, hazy, and tough for people with respiratory issues. New research from Washington University in St. Louis takes a new look at nighttime air chemistry, and how it can affect ozone levels the next day.

Using nighttime air chemistry to track ozone impact

St. Louis’ hazy summers can sometimes be too hot to handle for people with respiratory issues; increased ozone levels can make the air tough to breathe. A team of engineers at Washington University collaborated on a study of St. Louis’ late-summer air quality. They found that naturally occurring compounds processed in the night sky can have a big impact on ozone levels the next day.
Huntington’s Disease is a devastating, fatal, inherited disease that causes nerve cells in the brain to break down, and there is no cure. The School of Engineering's Rohit V. Pappu has received $4.5 million in grants to study new ways to stop the disease.

Huntington’s Disease target of $4.5 million in NIH grants

Rohit V. Pappu, the Edwin H. Murty Professor of Engineering in the School of Engineering & Applied Science at Washington University in St. Louis, has received two grants from the National Institutes of Health totaling more than $4.5 million to study the causes behind Huntington’s disease that may ultimately provide clues for a treatment or cure.
An artist's view of the stochastic resonance (SR) in an optomechanical resonator. The circular ring on the pillar resembles cross-section of a microtoroid resonator undergoing periodic mechanical oscillations (depicted as up (red) and down (blue) flapping) due to radiation pressure of light circulating within the structure. The bell-shaped curves represent the SNR as a function of noise in the system. Mechanical oscillations create a nonlinear system for the optical field and drive it into periodic and then to chaotic regime. Chaos with the help of optomechanical backaction noise enhances the signal-to-noise ratio (SNR) of a weak optical signal in the same resonator. Stochastic resonance occurs when the peaks in the noise coincide with the peaks of the weak signal. The SNR rises sharply to a maximum where SR occurs and then gradually decreases as the amount of noise is increased. (Image: B. Peng, S. K. Ozdemir, F. Monifi, L. Yang)

A new route to chaos

Researchers in the School of Engineering & Applied Science at Washington University in St. Louis have discovered a novel route to encode chaos on light in an optomechanical microresonator system.
Professor Lori Setton (right) and collaborators, including Pranali Tambe (left), a visiting research associate, are looking at new materials for regenerating soft tissue, which could lead to new therapies for back pain. (Photo: James Byard)

Back to health

Biomedical engineer Lori Setton’s collaborative research is pioneering new ways of providing relief to those who suffer neck and back pain.
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