genetics

Smoking while pregnant combined with genetic factors greatly increases the risk of severe ADHD.Past research has suggested that both genes and prenatal insults — such as exposure to alcohol and nicotine — can increase the risk of attention-deficit/hyperactivity disorder (ADHD). But the identified increases in risk have been very modest. Now, a team of Washington University scientists has found that when those factors are studied together, risk of a severe type of ADHD greatly increases.

Courtesy of the National Cancer InstituteBreast cancer cells stained brown using an antibody that recognizes malignant cellsClinical studies are proving that the genetic profile of a tumor can greatly influence its response to anticancer treatments. Matthew J. Ellis, M.D., Ph.D., at Washington University School of Medicine in St. Louis, is conducting research that aims to use the genetic profile of breast tumors to guide breast cancer therapy and ultimately to find new drugs for treating the disease.

An evolutionary and population biologist at Washington University in St. Louis says that Ernst Mayr’s theory of genetic revolution has been illustrated nicely in recent years in human genetic epidemiology and population biology studies. Alan R. Templeton, Ph.D., Washington University professor of biology in Arts & Sciences, said that there is an extensive documentation of genetic interaction over the past few years including his own genetic epidemiology studies of coronary artery disease (CAD).

In these brain sections of neonatal mice exposed to ethanol, mice deficient in certain enzymes (right) exhibit much more neurodegeneration as indicated by the black material in the dying neurons.Can you blame your genes if you can’t handle your liquor? A new study conducted at the School of Medicine may pave the way to finding out. Researchers found that the brain’s response to alcohol is partially under the influence of two genes. The genes, studied in both adult and newborn mice, were found to affect sensitivity to alcohol intoxication, interest in alcohol consumption and risk of developmental brain damage from alcohol.

In these brain sections of neonatal mice exposed to ethanol, mice deficient in certain enzymes (right) exhibit much more neurodegeneration as indicated by the black material in the dying neurons.Can you blame your genes if you can’t handle your liquor? A new study conducted at Washington University School of Medicine in St. Louis may pave the way to finding out. Researchers found that the brain’s response to alcohol is partially under the influence of two genes. The genes, studied in both adult and newborn mice, were found to affect sensitivity to alcohol intoxication, interest in alcohol consumption and risk of developmental brain damage from alcohol.

Washington University School of Medicine in St. Louis is a long-time leader in medical research and clinical practice. The school employs a number of experts in many areas of expertise, including health care policy issues. Under the direction of former dean William Peck, the university has established the Center for Health Policy to: Identify key […]

Are humans inherently good? The prevailing view in popular and scientific literature is that humans and animals are genetically driven to compete for survival, thus making all social interaction inherently selfish. According to this line of reasoning, known as sociobiology, even seemingly unselfish acts of altruism merely represent a species’ strategy to survive and preserve its genes. But Robert W. Sussman, Ph.D., a professor of anthropology in Arts & Sciences at Washington University in St. Louis, argues that this is a narrow and simplistic view of evolutionary theory that fails to explain many aspects of sociality among mammals in general and primates in particular. In “The Origins and Nature of Sociality,” a new book Sussman co-edited, he and other researchers challenge the proponents of sociobiology. “The ‘selfish gene’ hypothesis is inadequate,” Sussman says.

Some of the world’s top scholars on modern human origins will gather March 26 at Washington University in St. Louis for the last of a four-part series of “Conversations” on key issues that will affect the future of the university, the community and the world. Arts & Sciences is sponsoring the “Conversations,” which are free and open to the public, as part of the university’s 150th anniversary celebration. The “Modern Human Origins” Conversation will be held from 10 to 11:30 a.m. in Graham Chapel.

Heavy drinking is associated with a number of problems, but one surprisingly common problem involves not remembering large chunks of time. Called alcohol-induced blackouts, these memory losses were reported by more than 39 percent of women and more than 50 percent of men studied by researchers from Washington University School of Medicine in St. Louis and the Queensland Institute on Medical Research in Australia. The researchers also found that genetic factors play a big role in whether or not a person blacks out after heavy drinking. Studying more than 2,300 pairs of Australian twins, the research team was able to determine that more than 50 percent of the risk of blacking out seems to be controlled by genetic factors, and the role of genes is even greater in people who report blacking out multiple times.

Rebecca Dresser, an expert on biomedical research law and bioethics and the Daniel Noyes Kirby Professor of Law at Washington University in St. Louis, discusses the legal and ethical implications of stem cell research with Mike Sampson of KWMU’s “St. Louis on the Air” Nov. 25. Dresser is also a member of the President’s Council on Bioethics. Listen to the program from the KWMU Web site.