Disabling a gene in specific mouse cells, School of Medicine researchers have prevented mice from becoming obese, even after the animals had been fed a high-fat diet. The researchers blocked the activity of a gene in immune cells called macrophages, key inflammatory cells.
People with the genetic condition neurofibromatosis type 1 are prone to developing tumors on nervous system tissue. A new study from Washington University School of Medicine has found that the development and growth of such tumors are driven by nearby noncancerous neurons and immune cells.
In the COVID-19 wards of Barnes-Jewish Hospital, where Washington University physicians are fighting an exhausting battle against a new, baffling and sometimes lethal disease with the help of the hospital’s nurses, other medical professionals and support staff.
A biomarker in newborns may signal autism spectrum disorder months or even years before troubling symptoms develop and such diagnoses typically are made. Researchers at Washington University School of Medicine and Stanford University found that some newborns had very low levels of a neuropeptide years before their diagnoses with autism spectrum disorder.
Researchers at Washington University School of Medicine have transformed stem cells into insulin-producing cells. They used the CRISPR gene-editing tool to correct a defect that caused a form of diabetes, and implanted the cells into mice to reverse diabetes in the animals.
COVID-19 has touched seemingly every aspect of life, and that includes laboratory work on the Medical and Danforth campuses. Most labs have responded by taking steps to temporarily shut down bench work and take that work online, while others have shifted their focus to the coronavirus.
COVID-19 survivors are needed to donate blood plasma. Infectious diseases physicians at Washington University School of Medicine in St. Louis have developed an expanded access program to give blood plasma from COVID-19 survivors to critically ill patients.
Washington University School of Medicine is launching a clinical trial for patients hospitalized with COVID-19 at Barnes-Jewish Hospital. The study will investigate whether two different antimalarial drugs, including hydroxychloroquine, alone or in combination with a common antibiotic is effective in treating COVID-19 patients.
As the novel coronavirus has accelerated its spread throughout the Midwest and across the U.S., scores of students on the Washington University Medical Campus have mobilized to support health-care workers and the St. Louis community in the fight against the global pandemic.
Researchers from Washington University in St. Louis studied the gut microbiomes of wild apes in the Republic of Congo, of captive apes in zoos in the U.S., and of people from around the world and discovered that lifestyle is more important than geography or even species in determining the makeup of the gut microbiome.